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Bristol’s Opdivo scores again in tough-to-treat mesothelioma, this time flying solo

February 2, 2021 By Thomas Lamb

Last year at the World Conference on Lung Cancer, Bristol Myers Squibb made waves in mesothelioma with data showing its Opdivo – Yervoy duo could slash the risk of death in previously untreated patients. This year, it grabbed the spotlight with another survival win in the tough-to-treat disease.

Saturday, solo Opdivo became the first med to show in a randomized phase 3 trial that it could extend the lives of previously treated mesothelioma patients, cutting their risk of death by 28% against placebo. Those taking Opdivo lived for a median 9.2 months, versus 6.6 months for those in the placebo arm.

Opdivo also staved off disease worsening, slashing the risk of progression or death by 39%. At the one-year mark, 14.5% of Opdivo patients hadn’t seen their cancer worsen, and only 4.9% of placebo patients could say the same.

The results follow on the heels of Opdivo’s performance in first-line mesothelioma from the last WCLC meeting in August. In tandem with Yervoy, BMS’ checkpoint star pared down patients’ risk of death by 26% against chemo, a showing that ultimately earned the pair an FDA green light.

[Article continues at original source]


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Filed Under: Medicine, Mesothelioma Tagged With: mesothelioma, mesothelioma treatments, Opdivo

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