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Malignant pleural mesothelioma: from bedside to bench and from bench to bedside

June 10, 2019 By Thomas Lamb

Malignant pleural mesothelioma (MPM) is a rare but very aggressive cancer of the thin tissue layer (pleura) covering the lungs. The development of MPM is strongly linked to previous exposure to the fibrous mineral asbestos, which has been widely used until the 1980s, in particular in the building industry. Although patients are generally eligible … [Read more...]

Filed Under: Medicine, Mesothelioma Tagged With: asbestos-related cancer, malignant mesothelioma, malignant pleural mesothelioma (MPM), mesothelioma, mesothelioma diagnosis, mesothelioma treatments

NIOSH considers mesothelioma registry; seeks input

May 28, 2019 By Thomas Lamb

The [ National Institute for Occupational Safety and Health (NIOSH) ] is gauging the feasibility of a national [ mesothelioma registry ] intended to track cases of mesothelioma, a rare form of cancer linked to on-the-job exposure to asbestos. According to a Request for Information published in the April 8 Federal Register, the agency is asking … [Read more...]

Filed Under: Case Reports, Facts, Mesothelioma, Uncategorized Tagged With: asbestos exposure, asbestos-related cancer, mesothelioma, National Institute for Occupational Safety and Health (NIOSH)

More than 200 teachers died from asbestos – and kids are at risk in classroom

May 8, 2019 By Thomas Lamb

More than 200 teachers have died in the past 10 years from the effects of being exposed to asbestos. And for each teacher fatality, nine ex-pupils can also be expected to fall victim to the silent killer, a study claims – an average of almost 200 per year. Breathing in asbestos fibres can lead to mesothelioma, a cancer that develops in the … [Read more...]

Filed Under: Asbestos, Exposure, Mesothelioma Tagged With: asbestos, asbestos exposure, asbestos fibers, asbestos-related cancer, Children, Classrooms, malignant mesothelioma, mesothelioma, Schools, Teachers

Dr. Goldberg Discusses the Diagnosis of Mesothelioma (Short Video)

April 23, 2019 By Thomas Lamb

Sarah B. Goldberg, MD, MPH, assistant professor of medicine, Yale School of Medicine and Yale Cancer Center, discusses the diagnosis of mesothelioma. This is an extremely rare disease that is usually seen in patients with prior asbestos exposure, Goldberg says. However, mesothelioma can be seen occasionally in patients without prior exposure to … [Read more...]

Filed Under: Asbestos, Medicine, Mesothelioma Tagged With: asbestos exposure, asbestos-related cancer, malignant mesothelioma, mesothelioma, mesothelioma diagnosis

Avelumab may benefit some patients with advanced unresectable mesothelioma

February 20, 2019 By Thomas Lamb

The anti-programmed cell death ligand 1 (PD-L1) monoclonal antibody avelumab is well tolerated and shows antitumor activity in some patients with previously treated unresectable mesothelioma, according to results from a single-arm trial. “Immune-checkpoint inhibitors result in clinical benefit in a small subset of patients with mesothelioma, but … [Read more...]

Filed Under: Medicine, Mesothelioma Tagged With: asbestos-related cancer, malignant mesothelioma, mesothelioma, mesothelioma treatments

Pleural mesothelioma: tackling a deadly cancer

February 11, 2019 By Thomas Lamb

A new study from the University of Pittsburgh has highlighted six factors that are associated with improved survival in patients with mesothelioma; age under 45 years, female, epithelioid histological subtype, peritoneal mesothelioma, stage 1 cancer, and being treated with both surgery and chemotherapy. This knowledge, together with recent reports … [Read more...]

Filed Under: Medicine, Mesothelioma Tagged With: asbestos-related cancer, malignant mesothelioma, malignant pleural mesothelioma (MPM), mesothelioma, mesothelioma treatments

J&J’s Risk From Tainted-Talc Lawsuits Only Gets Bigger in 2019

January 3, 2019 By Thomas Lamb

Johnson & Johnson paid a steep price this year for claims that its celebrated baby powder was contaminated with asbestos. Problem is, 2019 could be even worse. A jury ordered the company in July to pay $4.69 billion to 22 women who blamed the talc-based product for causing their ovarian cancer. The prospect of similar judgments helped erase … [Read more...]

Filed Under: Asbestos, Lawsuits, Mesothelioma, Talc Tagged With: asbestos talc lawsuits, asbestos-contaminated talc, asbestos-infused talc, asbestos-related cancer, malignant mesothelioma, mesothelioma, mesothelioma lawsuits, talcum powder mesothelioma lawsuits

Jury clears J&J of liability in California talc cancer case

November 23, 2018 By Thomas Lamb

A California jury on [November 14, 2018] cleared Johnson & Johnson of liability in a case involving a woman who alleged that the company’s talc-based products, including its baby powder, contain asbestos and caused her cancer, the company said. The jury in Humboldt County Superior Court in Eureka, California rejected claims by Carla Allen … [Read more...]

Filed Under: Asbestos, Claims, Lawsuits, Mesothelioma, Talc Tagged With: asbestos lawsuits, asbestos talc lawsuits, asbestos-contaminated talc, asbestos-infused talc, asbestos-related cancer, malignant mesothelioma, mesothelioma lawsuits

Differentiating epithelioid mesothelioma from lung adenocarcinoma — MUC21 is a novel, negative immunohistochemical marker

October 25, 2018 By Thomas Lamb

A recent medical study investigated the potential usefulness of mucin 21 (MUC21), as a novel, negative diagnostic marker for purpose of differentiating epithelioid mesothelioma from lung adenocarcinoma.  In order to analyze the expression of MUC21 by immunohistochemistry, 70 epithelioid mesothelioma and 70 lung adenocarcinoma cases were examined.  … [Read more...]

Filed Under: Lung Cancer, Mesothelioma Tagged With: asbestos-related cancer, lung adenocarcinoma, lung cancer, malignant mesothelioma, malignant pleural mesothelioma (MPM), mesothelioma, mesothelioma diagnosis

Early Signs of Efficacy Seen With Mesothelin CAR T-Cell Therapy

August 21, 2018 By Thomas Lamb

Mesothelin-targeted chimeric antigen receptor (CAR) T-cell therapy has shown early evidence of efficacy in a phase I trial of patients with malignant pleural disease and mesothelioma, non–small cell lung cancer, or breast cancer (NCT02414269). Additionally, significant responses were seen in patients who went on to receive subsequent PD-1 … [Read more...]

Filed Under: Lung Cancer, Medicine, Mesothelioma Tagged With: asbestos-related cancer, malignant mesothelioma, malignant pleural mesothelioma (MPM), mesothelioma, mesothelioma treatments

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