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PD-1 Blockade Mitigates Surgery-Induced Immunosuppression and Increases the Efficacy of Photodynamic Therapy for Pleural Mesothelioma

May 27, 2025 By Thomas Lamb

Lung-sparing radical pleurectomy with intraoperative photodynamic therapy (PDT) demonstrates remarkable survival for patients with pleural mesothelioma. Nevertheless, most patients treated with this multimodal approach will develop local tumor recurrence. An understanding of potential causes of treatment failure is central to developing mitigation … [Read more...]

Filed Under: Medicine, Mesothelioma Tagged With: mesothelioma, mesothelioma treatments, photodynamic therapy, pleural mesothelioma, pleurectomy

The global burden of mesothelioma and its association with asbestos bans, 1990–2021: a population-based study

May 15, 2025 By Thomas Lamb

Background:  Mesothelioma, as a lethal consequence of asbestos exposure, poses a significant threat to high-risk populations. The Global Burden of Disease (GBD) 2021 update provides an opportunity to examine current mesothelioma epidemiology and assess whether asbestos bans have effectively reduced mesothelioma incidence over a longer time span … [Read more...]

Filed Under: Asbestos, Mesothelioma Tagged With: asbestos, asbestos ban, asbestos exposure, malignant pleural mesothelioma (MPM), mesothelioma

Diagnostic Differentiation Between Two Rare Entities—Metastatic Peritoneal Mesothelioma With Duodenal Involvement and Duodenal Synovial Sarcoma: A Case Report

April 18, 2025 By Thomas Lamb

Abstract:  This case report highlights the diagnostic challenges in distinguishing between metastatic peritoneal mesothelioma with duodenal involvement and synovial sarcoma of the duodenum, two rare and complex entities. A 59-year-old woman presented with nonspecific abdominal symptoms, and imaging revealed a heterogeneous lesion between the right … [Read more...]

Filed Under: Medicine, Mesothelioma Tagged With: mesothelioma, peritoneal mesothelioma

A Review of Job Assignments and Asbestos Workplace Exposure Measurements for TAWP Mesothelioma Deaths Through 2011

March 20, 2025 By Thomas Lamb

ABSTRACT Introduction: Asbestos workers have a higher risk of developing mesothelioma; however, few studies have looked at specific jobs and job locations within asbestos factories. The purpose of this study was to investigate asbestos exposure in different job locations of the Tyler, Texas asbestos plant to determine if there was a relationship … [Read more...]

Filed Under: Asbestos, Exposure, Mesothelioma Tagged With: asbestos exposure, mesothelioma

Multimodality Therapy Including Pleurectomy/Decortication in Pleural Mesothelioma: Long-Term Outcomes in 152 Consecutive Patients A Retrospective Cohort Study

March 5, 2025 By Thomas Lamb

Objective:  Evaluate the long-term outcomes of pleurectomy decortication, systemic chemotherapy and prophylactic radiotherapy in pleural mesothelioma (PM). Summary background data:  There is no known cure for PM and cytoreductive surgery remains controversial. Methods:  Retrospective analysis of a cohort of patients treated consecutively … [Read more...]

Filed Under: Medicine, Mesothelioma Tagged With: chemotherapy, pleural mesothelioma, pleurectomy decortication, Radiotherapy

Recent Advances in Mesothelioma Treatment: Immunotherapy, Advanced Cell Therapy, and Other Innovative Therapeutic Modalities

February 19, 2025 By Thomas Lamb

Mesothelioma is a malignant condition arising from the pleura and peritoneum that is closely related to asbestos exposure [1]. Due to the prolonged time needed for one to fully develop mesothelioma, difficulty in diagnosing this condition early, its quick progression once manifested, and the limited [ mesothelioma treatment ] options, the prognosis … [Read more...]

Filed Under: Medicine, Mesothelioma Tagged With: mesothelioma, mesothelioma treatments

Treatment of Pleural Mesothelioma: ASCO Guideline Update

January 31, 2025 By Thomas Lamb

Since the initial [American Society of Clinical Oncologists (ASCO)] clinical practice guideline on the treatment of malignant pleural mesothelioma (PM) was published in 2018, considerable progress has been made which has changed not only the management but even the name of this disease. This guideline update focuses on four key areas: the role of … [Read more...]

Filed Under: Medicine, Mesothelioma Tagged With: malignant pleural mesothelioma (MPM), mesothelioma treatments, pleural mesothelioma

The presence of pleural effusion is an independent prognostic factor in patients with malignant pleural mesothelioma

January 6, 2025 By Thomas Lamb

Abstract:  Malignant pleural mesothelioma (MPM) is a rare form of thoracic malignancy with a poor prognosis. Pleural effusion (PE) occurs in the majority of patients with MPM; however, its impact on MPM outcomes remains controversial. We searched for eligible patients from the Surveillance, Epidemiology, and End Results (SEER) database, and … [Read more...]

Filed Under: Medicine, Mesothelioma Tagged With: malignant pleural mesothelioma (MPM), mesothelioma, mesothelioma diagnosis, pleural effusions

Diffuse Pleural Mesothelioma: A Challenge in Early Diagnosis

December 16, 2024 By Thomas Lamb

Abstract:  We present the clinical case of a 58-year-old female patient, a smoker with occupational exposure to respiratory toxins, who was admitted to our clinic following evaluation in an emergency department, where she was diagnosed with a moderate right pleural effusion. Upon admission, the patient exhibited respiratory symptoms, including … [Read more...]

Filed Under: Medicine, Mesothelioma Tagged With: mesothelioma, mesothelioma diagnosis, pleural effusions, pleural mesothelioma

A Case Report of Peritoneal Mesothelioma as an Acute Abdomen Mimic: A Rare Presentation and Diagnostic Challenges

November 29, 2024 By Thomas Lamb

Abstract:  Malignant peritoneal mesothelioma (MPM) is a rare and aggressive cancer often linked to asbestos exposure. This case report presents a 60-year-old man with a history of asbestos exposure who developed MPM, initially presenting with acute abdominal pain, an uncommon mimic of the acute abdomen. Diagnosing MPM is challenging due to its … [Read more...]

Filed Under: Mesothelioma Tagged With: peritoneal malignant mesothelioma, peritoneal mesothelioma

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