Malignant pleural mesothelioma (MPM) is an aggressive asbestos-related tumour with poor prognosis. To date, a multimodality treatment, including chemotherapy and surgery, with or without radiotherapy, is the gold standard therapy for selected patients with epithelioid and early-stage MPM. In this setting, the goal of surgery is to achieve the … [Read more...]
EPA rule would finally ban asbestos, carcinogen still in use
The Environmental Protection Agency on Tuesday proposed a rule to finally ban asbestos, a carcinogen that is still used in some chlorine bleach, brake pads and other products and kills thousands of Americans every year. The proposal marks a major expansion of EPA regulation under a landmark 2016 law that overhauled rules governing tens of … [Read more...]
Asbestos Exposure and Malignant Mesothelioma in Construction Workers—Epidemiological Remarks by the Italian National Mesothelioma Registry (ReNaM)
Notwithstanding the ban in 1992, asbestos exposure for workers in the construction sector in Italy remains a concern. The purpose of this study is to describe the characteristics of malignant mesothelioma (MM) cases recorded by the Italian registry (ReNaM) among construction workers. Incident mesothelioma cases with a definite asbestos exposure … [Read more...]
Environmental exposure to asbestos and the risk of lung cancer: a systematic review and meta-analysis
Asbestos is a carcinogen associated with lung cancer, but few studies have examined the increased risk of lung cancer due to environmental asbestos exposure. We performed a systematic review and meta-analysis to evaluate the association between environmental asbestos exposure and lung cancer. We searched for articles on non-occupational or … [Read more...]
Health groups sue to make EPA evaluate ‘legacy’ asbestos risk
Health and environmental groups have sued the Environmental Protection Agency, seeking a court order compelling it to evaluate the risks posed by so-called "legacy" asbestos used in old products and buildings. In a complaint filed Tuesday in federal court in San Francisco, groups including the nonprofit Asbestos Disease Awareness Organization … [Read more...]
Effect of Asbestos Exposure on the Frequency of EGFR Mutations and ALK/ROS1 Rearrangements in Patients With Lung Adenocarcinoma: A Multicentric Study
Objective: The aim of this study is to investigate the effect of asbestos exposure on cancer-driver mutations. Methods: Between January 2014 and September 2018, epidermal growth factor receptor (EGFR), anaplastic lymphoma receptor tyrosine kinase (ALK), and c-ros oncogene 1 receptor tyrosine kinase gene (ROS1) alterations, demographic … [Read more...]
What is the link between asbestos and lung cancer?
Asbestos is a material that people have used as insulation since the Industrial Revolution. There are strong associations between asbestos and certain types of cancer, including lung cancer and mesothelioma, which is a type of cancer that affects the mesothelial cells. According to the American Cancer Society, several expert agencies, including … [Read more...]
New Options Spark Sequencing and Biomarker Trials in Mesothelioma
Now that a new standard of care has been established in frontline mesothelioma, clinical trials are needed to evaluate optimal sequencing with checkpoint inhibitors in the salvage setting and determine whether biomarkers of response to immunotherapy could further tailor treatment to individual patients, said Anne S. Tsao, MD, during a virtual … [Read more...]
Talc-Based Beauty Products Found to be Contaminated with Asbestos
Talc-based beauty products have been found to be contaminated with asbestos according to some recent news headlines. How can this be? For years, cosmetics and personal care products have included a mineral ingredient called talc in their manufacturing process. Talc's original intention was to improve the texture and feel of products, absorb … [Read more...]
Mesothelioma risk among those exposed to chrysotile asbestos only and mixtures that include amphibole: a case–control study in the USA, 1975–1980
Objectives Occupational asbestos exposure is causally linked to mesothelioma. However, whether exposure to only chrysotile asbestos is associated with mesothelioma risk, and the heterogeneity in risk by different fibre types/lengths remains unclear. We investigated whether mesothelioma risk differs among workers exposed to only chrysotile … [Read more...]