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A Gelatinous Pleural Effusion as a Diagnostic Clue

March 15, 2023 By Thomas Lamb

Pleural effusion is a common presentation of several pathologies, and the determination of its cause is facilitated by macroscopic, biochemical, microbiological, and cellular analysis. A systematic approach to analyzing the fluid allows for a reduction in clinical diagnoses. Only a select number of diagnoses can be established definitively by … [Read more...]

Filed Under: Medicine, Mesothelioma Tagged With: malignant pleural mesothelioma (MPM), mesothelioma, mesothelioma diagnosis

Pembrolizumab/Lenvatinib Combo Shows Positive Clinical Activity in Recurrent Pleural Mesothelioma

September 13, 2022 By Thomas Lamb

The combination of pembrolizumab (Keytruda), and lenvatinib (Lenvima) demonstrated promising clinical activity with no unexpected toxicities in patients with malignant pleural mesothelioma (MPM), according to results from the PEMMELA study (NCT04287829) presented at the International Association for the Study of Lung Cancer 2022 World … [Read more...]

Filed Under: Medicine, Mesothelioma Tagged With: Keytruda, Lenvima, malignant pleural mesothelioma (MPM), mesothelioma, mesothelioma treatments

Galinpepimut-S Plus Nivolumab Extends Survival in Malignant Pleural Mesothelioma

August 3, 2022 By Thomas Lamb

The combination of galinpepimut-S and nivolumab (Opdivo) was found to extend survival in patients with malignant pleural mesothelioma who were either refractory to, or who had relapsed after, at least 1 line of standard therapy, according to updated data from a phase 1 trial (NCT04040231). The median overall survival (OS), which was calculated … [Read more...]

Filed Under: Medicine, Mesothelioma Tagged With: Galinpepimut-S, malignant pleural mesothelioma (MPM), mesothelioma treatments, Opdivo

Second Surgery for Recurrent Malignant Pleural Mesothelioma after Multimodality Treatment: A Systematic Review

June 30, 2022 By Thomas Lamb

Malignant pleural mesothelioma (MPM) is an aggressive asbestos-related tumour with poor prognosis. To date, a multimodality treatment, including chemotherapy and surgery, with or without radiotherapy, is the gold standard therapy for selected patients with epithelioid and early-stage MPM. In this setting, the goal of surgery is to achieve the … [Read more...]

Filed Under: Asbestos, Medicine, Mesothelioma Tagged With: asbestos, asbestos exposure, asbestos-related cancer, malignant pleural mesothelioma (MPM), mesothelioma, mesothelioma treatments

Clinical-pathological characteristics and prognostic factors for malignant peritoneal mesothelioma in the elderly

June 22, 2022 By Thomas Lamb

Background:  Malignant peritoneal mesothelioma (MPM) is a rare disease characterized by atypical symptoms, difficult diagnosis, variable course and poor prognosis, and it develops mainly in elderly individuals. The authors aimed to identify the clinical-pathological characteristics, prognosis, and prognostic factors in elderly [ malignant … [Read more...]

Filed Under: Medicine, Mesothelioma Tagged With: mesothelioma, peritoneal malignant mesothelioma, peritoneal mesothelioma

A Case Report of Hypophosphatemia Leading to the Diagnosis of Mesothelioma

June 8, 2022 By Thomas Lamb

Hypophosphatemia can be commonly encountered as an electrolyte imbalance and is defined as a value less than 0.8 mmol/l (2.5 mg/dl). It can be an incidental finding, but it is not uncommon to see it presenting with varied symptoms. It is good to have a clear diagnostic approach to this so adequate treatment can be instated. We present a … [Read more...]

Filed Under: Medicine, Mesothelioma Tagged With: hypophosphatemia, malignant mesothelioma, mesothelioma, mesothelioma diagnosis

Unexplained Pleural Effusion Leads to the Revelation of a Malignant Mesothelioma: A Case Report

April 29, 2022 By Thomas Lamb

Abstract:  Malignant mesothelioma is a rare and aggressive cancer that usually affects subjects with prior asbestos exposure, a major risk factor that has been widely known as carcinogenic, and its use is now controlled if not banned in many areas of the world. Malignant mesothelioma originates from mesothelial surface cells covering the serous … [Read more...]

Filed Under: Medicine, Mesothelioma Tagged With: malignant mesothelioma, mesothelioma diagnosis, pleural effusions

Pericardial Mesothelioma Presenting as Constrictive Pericarditis

April 21, 2022 By Thomas Lamb

Abstract:  This case report presents a 60-year-old gentleman with a significant smoking history and possible asbestos exposure who was referred to the emergency department for atrial fibrillation with a rapid ventricular rate and symptoms of heart failure. Labs showed normal brain natriuretic peptide and troponin I. His echocardiography finding … [Read more...]

Filed Under: Medicine, Mesothelioma Tagged With: malignant mesothelioma, mesothelioma, mesothelioma diagnosis, pericardial mesothelioma

Abemaciclib for Previously Treated Patients With p16ink4A-Deficient Mesothelioma

April 15, 2022 By Thomas Lamb

As reported in The Lancet Oncology by Dean A. Fennell, FRCP, and colleagues, a phase II trial (MiST2) showed the activity of [ Verzenio (abemaciclib) ] in previously treated patients with p16ink4A-deficient malignant mesothelioma. As stated by the investigators, “Genetically stratified therapy for malignant mesothelioma is unavailable. … [Read more...]

Filed Under: Medicine, Mesothelioma Tagged With: abemaciclib, malignant mesothelioma, mesothelioma, mesothelioma treatments, Verzenio

Early Clinical Activity With CDK4/6 Inhibitor in Pretreated Mesothelioma

March 11, 2022 By Thomas Lamb

[Verzenio (abemaciclib), a drug that has proven effective in breast cancer,] showed preliminary activity in its first-ever clinical trial in mesothelioma. The cyclin-dependent kinase (CDK) 4/6 inhibitor [Verzenio (abemaciclib)] achieved disease control at 12 weeks in 14 of 26 patients with progressive mesothelioma associated with a CDKN2A … [Read more...]

Filed Under: Medicine, Mesothelioma Tagged With: abemaciclib, malignant mesothelioma, mesothelioma, mesothelioma treatments, Verzenio

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