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Surgery for malignant pleural mesothelioma after radiotherapy (SMART): final results from a single-centre, phase 2 trial

January 14, 2021 By Thomas Lamb

Background:  A novel approach for managing malignant pleural mesothelioma, surgery for mesothelioma after radiotherapy (SMART), consisting of a short accelerated course of high-dose, hemithoracic, intensity modulated radiotherapy (IMRT) followed by extrapleural pneumonectomy was developed. The aim of this study was to evaluate the clinical … [Read more...]

Filed Under: Medicine, Mesothelioma Tagged With: chemotherapy, extrapleural pneumonectomy, malignant pleural mesothelioma (MPM), mesothelioma, mesothelioma treatments, Radiotherapy

Durvalumab with first-line chemotherapy in previously untreated malignant pleural mesothelioma (DREAM): a multicentre, single-arm, phase 2 trial with a safety run-in

October 2, 2020 By Thomas Lamb

Background:  There is a strong unmet need to improve systemic therapy in mesothelioma. Chemotherapy with cisplatin and pemetrexed improves survival in malignant pleural mesothelioma, and immune checkpoint inhibitors are an emerging treatment in this disease. We aimed to evaluate the activity of durvalumab, an anti-PD-L1 antibody, given during … [Read more...]

Filed Under: Medicine, Mesothelioma Tagged With: chemotherapy, cisplatin, malignant mesothelioma, malignant pleural mesothelioma (MPM), mesothelioma, mesothelioma treatments, pemetrexed

[Transforming Growth Factor Alpha] Promotes Chemoresistance of Malignant Pleural Mesothelioma

June 25, 2020 By Thomas Lamb

Background: There is no standard chemotherapy for refractory or relapsing malignant pleural mesothelioma (MPM). Our previous reports nevertheless indicated that a combination of an anthracycline (doxorubicin) and a lysine deacetylase inhibitor (valproic acid, VPA) synergize to induce the apoptosis of MPM cells and reduce tumor growth in mouse … [Read more...]

Filed Under: Medicine, Mesothelioma Tagged With: chemotherapy, malignant pleural mesothelioma (MPM), mesothelioma treatments

Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy for peritoneal mesothelioma: patient selection and special considerations

May 16, 2019 By Thomas Lamb

Abstract: Malignant peritoneal mesothelioma (MPM) is a rare, aggressive malignancy that typically presents with vague symptoms, ascites, and/or diffuse peritoneal studding. Despite findings of advanced disease within the peritoneal cavity, spread beyond the abdomen is uncommon. Although advances in systemic chemotherapy have been made, … [Read more...]

Filed Under: Medicine, Mesothelioma Tagged With: chemotherapy, malignant mesothelioma, mesothelioma, mesothelioma treatments, peritoneal mesothelioma

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TJL@LambLawOffice.com

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1908 Eastwood Road, Suite 225
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910-256-2971 | 800-426-9535
TJL@LambLawOffice.com

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