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FDA Approves Pembrolizumab Plus Chemo for Unresectable Advanced or Metastatic Malignant Pleural Mesothelioma

September 18, 2024 By Thomas Lamb

The FDA has approved [ Keytruda (pembrolizumab) ] plus pemetrexed and platinum chemotherapy in the frontline treatment of patients with unresectable advanced or metastatic malignant pleural mesothelioma. Data from the phase 2/3 KEYNOTE-483 study (NCT02784171) showed that [ Keytruda (pembrolizumab) ] plus chemotherapy (n = 222) significantly … [Read more...]

Filed Under: Medicine, Mesothelioma Tagged With: chemotherapy, Keytruda, malignant mesothelioma, malignant pleural mesothelioma (MPM), mesothelioma treatments, pembrolizumab, pemetrexed, pleural mesothelioma

Merck reports positive data from malignant pleural mesothelioma trial

May 24, 2023 By Thomas Lamb

Merck and the Canadian Cancer Trials Group (CCTG) have reported positive data from the Phase II/III CCTG IND.227/KEYNOTE-483 trial of Keytruda, along with chemotherapy, as first-line treatment for advanced malignant pleural mesothelioma patients. The open-label, randomised Phase II/III trial has been designed for assessing the combination of … [Read more...]

Filed Under: Medicine, Mesothelioma Tagged With: Keytruda, malignant pleural mesothelioma (MPM), mesothelioma, mesothelioma treatments

Pembrolizumab/Lenvatinib Combo Shows Positive Clinical Activity in Recurrent Pleural Mesothelioma

September 13, 2022 By Thomas Lamb

The combination of pembrolizumab (Keytruda), and lenvatinib (Lenvima) demonstrated promising clinical activity with no unexpected toxicities in patients with malignant pleural mesothelioma (MPM), according to results from the PEMMELA study (NCT04287829) presented at the International Association for the Study of Lung Cancer 2022 World … [Read more...]

Filed Under: Medicine, Mesothelioma Tagged With: Keytruda, Lenvima, malignant pleural mesothelioma (MPM), mesothelioma, mesothelioma treatments

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