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Nivo/Ipi Combo Now ‘Standard of Care’ in Mesothelioma

October 12, 2021 By Thomas Lamb

The [ combination immunotherapy consisting ] of nivolumab (Opdivo) and ipilimumab (Yervoy) offers a durable, long-term survival benefit over chemotherapy for patients with unresectable malignant pleural mesothelioma (MPM), confirms a 3-year updated analysis of the CheckMate 743 trial. After 3 years, 23% of patients who received combination … [Read more...]

Filed Under: Medicine, Mesothelioma Tagged With: combination immunotherapy, Ipilimumab, malignant pleural mesothelioma (MPM), mesothelioma, mesothelioma treatments, Nivolumab, Opdivo, Yervoy

Access to care varies greatly among patients with malignant pleural mesothelioma

October 4, 2021 By Thomas Lamb

Access to care varied significantly among patients with stage I to stage III malignant pleural mesothelioma, according to study results. The findings — presented at International Association for the Study of Lung Cancer World Conference on Lung Cancer — showed variations in access based on factors such as distance to treatment facility, as well … [Read more...]

Filed Under: Medicine, Mesothelioma Tagged With: malignant mesothelioma, malignant pleural mesothelioma (MPM), mesothelioma diagnosis, mesothelioma treatments

More Data in Support of Surgery for Malignant Pleural Mesothelioma

September 28, 2021 By Thomas Lamb

Patients with malignant pleural mesothelioma (MPM) lived 6 months longer, on average, when they had surgery in addition to chemotherapy, a large retrospective analysis showed. The addition of surgery to combination chemotherapy resulted in a median overall survival (OS) of 22 months as compared with 16 months with chemotherapy alone. Twice as … [Read more...]

Filed Under: Medicine, Mesothelioma Tagged With: malignant pleural mesothelioma (MPM), mesothelioma, mesothelioma treatments

Surgery After Radiotherapy May Improve Outcomes in Patients with Malignant Pleural Mesothelioma

September 2, 2021 By Thomas Lamb

A particular surgery performed following the completion of radiotherapy treatment among a group of patients with malignant pleural mesothelioma was associated with improved outcomes including overall survival, according to study results recently published in Lancet Oncology. “Different treatment strategies have been tried (for malignant pleural … [Read more...]

Filed Under: Medicine, Mesothelioma Tagged With: malignant pleural mesothelioma (MPM), mesothelioma, mesothelioma treatments

Tongue: the unusual site in malignant pleural mesothelioma

August 26, 2021 By Thomas Lamb

Malignant mesotheliomas (MMs) are malignancies of the mesothelium, with primary deposits originating in the pleura, peritoneum, pericardium and the tunica vaginalis (ie, testicular). Metastatic spread is commonly reported to affect the liver, adrenal glands, kidney and contralateral lung (in cases of malignant pleural mesothelioma). Metastases to … [Read more...]

Filed Under: Medicine, Mesothelioma, Uncategorized Tagged With: malignant mesothelioma, malignant pleural mesothelioma (MPM), mesothelioma

Comparative effectiveness of second-line immune checkpoint inhibitor therapy versus chemotherapy for malignant pleural mesothelioma

August 10, 2021 By Thomas Lamb

Objectives: Second-line immune checkpoint inhibition (ICI) was recently shown to have a survival advantage over placebo in malignant pleural mesothelioma (MPM), but the survival comparison to chemotherapy in patients with MPM receiving routine clinical care is unknown. Our objective was to examine the effectiveness of second-line [ immune … [Read more...]

Filed Under: Medicine, Mesothelioma Tagged With: malignant mesothelioma, malignant pleural mesothelioma (MPM), mesothelioma, mesothelioma treatments

Neoadjuvant pemetrexed plus cisplatin followed by pleurectomy for malignant pleural mesothelioma.

August 4, 2021 By Thomas Lamb

PURPOSE: Despite becoming the preferred surgical technique for malignant pleural mesothelioma, pleurectomy/decortication has received few prospective clinical trials. Therefore, the Japan Mesothelioma Interest Group conducted a prospective multi-institutional study to evaluate the feasibility of neoadjuvant chemotherapy followed by … [Read more...]

Filed Under: Medicine, Mesothelioma Tagged With: decortication, malignant mesothelioma, malignant pleural mesothelioma (MPM), mesothelioma, mesothelioma treatments, pleurectomy

A Case of Pulmonary Embolism with Sarcomatoid Malignant Pleural Mesothelioma with Long-Term Pleural Effusion

July 16, 2021 By Thomas Lamb

Background: Malignant pleural mesothelioma (MPM) is a highly aggressive tumor that originates from pleural mesothelial cells. In recent years, with the development of asbestos-related industries and the increase in air pollution, its incidence has been increased. The incidence of pulmonary embolism combined with sarcomatoid MPM is very low and the … [Read more...]

Filed Under: Medicine, Mesothelioma Tagged With: malignant pleural mesothelioma (MPM), mesothelioma, Sarcomatoid Malignant Pleural Mesothelioma

The association between pleural fluid exposure and survival in pleural mesothelioma

June 23, 2021 By Thomas Lamb

Background:  Most patients with malignant pleural mesothelioma (MPM) present with malignant pleural effusion (MPE). There is in vitro evidence that MPE may not be a simple bystander of malignancy, but potentially has biological properties improving cancer cell survival and promoting cancer progression. If this is the case, MPE management may need … [Read more...]

Filed Under: Medicine, Mesothelioma Tagged With: malignant pleural mesothelioma (MPM), mesothelioma, mesothelioma treatments

Vinorelbine extends PFS in relapsed malignant pleural mesothelioma

June 10, 2021 By Thomas Lamb

Vinorelbine combined with active supportive care conferred superior [ progression-free survival (PFS) ] compared with active supportive care alone among patients with relapsed malignant pleural mesothelioma, according to phase 2 study results. “All patients with malignant pleural mesothelioma eventually relapse following standard chemotherapy … [Read more...]

Filed Under: Medicine, Mesothelioma Tagged With: malignant pleural mesothelioma (MPM), mesothelioma, mesothelioma treatments

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