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Multimodality Therapy Including Pleurectomy/Decortication in Pleural Mesothelioma: Long-Term Outcomes in 152 Consecutive Patients A Retrospective Cohort Study

March 5, 2025 By Thomas Lamb

Objective:  Evaluate the long-term outcomes of pleurectomy decortication, systemic chemotherapy and prophylactic radiotherapy in pleural mesothelioma (PM). Summary background data:  There is no known cure for PM and cytoreductive surgery remains controversial. Methods:  Retrospective analysis of a cohort of patients treated consecutively … [Read more...]

Filed Under: Medicine, Mesothelioma Tagged With: chemotherapy, pleural mesothelioma, pleurectomy decortication, Radiotherapy

Treatment of Pleural Mesothelioma: ASCO Guideline Update

January 31, 2025 By Thomas Lamb

Since the initial [American Society of Clinical Oncologists (ASCO)] clinical practice guideline on the treatment of malignant pleural mesothelioma (PM) was published in 2018, considerable progress has been made which has changed not only the management but even the name of this disease. This guideline update focuses on four key areas: the role of … [Read more...]

Filed Under: Medicine, Mesothelioma Tagged With: malignant pleural mesothelioma (MPM), mesothelioma treatments, pleural mesothelioma

Diffuse Pleural Mesothelioma: A Challenge in Early Diagnosis

December 16, 2024 By Thomas Lamb

Abstract:  We present the clinical case of a 58-year-old female patient, a smoker with occupational exposure to respiratory toxins, who was admitted to our clinic following evaluation in an emergency department, where she was diagnosed with a moderate right pleural effusion. Upon admission, the patient exhibited respiratory symptoms, including … [Read more...]

Filed Under: Medicine, Mesothelioma Tagged With: mesothelioma, mesothelioma diagnosis, pleural effusions, pleural mesothelioma

Immunotherapy for Treatment of Pleural Mesothelioma: Current and Emerging Therapeutic Strategies

October 10, 2024 By Thomas Lamb

Pleural mesothelioma is a rare malignancy associated with asbestos exposure and very poor prognosis, with a 5-year overall survival of 12%. Outcomes may vary according to stage at time of diagnosis and histologic subtype. Most recently, clinical trials utilizing dual checkpoint inhibitor regimens and chemotherapy in combination with immune … [Read more...]

Filed Under: Medicine, Mesothelioma Tagged With: asbestos exposure, Immune checkpoint inhibitor (ICI), Immunotherapy, mesothelioma treatments, pleural mesothelioma

FDA Approves Pembrolizumab Plus Chemo for Unresectable Advanced or Metastatic Malignant Pleural Mesothelioma

September 18, 2024 By Thomas Lamb

The FDA has approved [ Keytruda (pembrolizumab) ] plus pemetrexed and platinum chemotherapy in the frontline treatment of patients with unresectable advanced or metastatic malignant pleural mesothelioma. Data from the phase 2/3 KEYNOTE-483 study (NCT02784171) showed that [ Keytruda (pembrolizumab) ] plus chemotherapy (n = 222) significantly … [Read more...]

Filed Under: Medicine, Mesothelioma Tagged With: chemotherapy, Keytruda, malignant mesothelioma, malignant pleural mesothelioma (MPM), mesothelioma treatments, pembrolizumab, pemetrexed, pleural mesothelioma

Extended pleurectomy decortication and chemotherapy versus chemotherapy alone for pleural mesothelioma (MARS 2): a phase 3 randomised controlled trial

July 11, 2024 By Thomas Lamb

Background:  Extended pleurectomy decortication for complete macroscopic resection for pleural mesothelioma has never been evaluated in a randomised trial. The aim of this study was to compare outcomes after extended pleurectomy decortication plus chemotherapy versus chemotherapy alone. Methods:  MARS 2 was a phase 3, national, multicentre, … [Read more...]

Filed Under: Medicine, Mesothelioma Tagged With: chemotherapy, decortication, extended pleurectomy decortication, mesothelioma, pleural mesothelioma, pleurectomy

Predictive potential of MRI in differentiating the predominant component in biphasic pleural mesothelioma

May 28, 2024 By Thomas Lamb

Purpose:  To assess the potential of apparent diffusion coefficient (ADC) values derived from diffusion weighted (DW) MRI preoperatively to predict the predominant histologic component among biphasic pleural mesothelioma (PM) tumors. Methods:  ADC maps were generated from DW MRI scans. Histology and predominant component of [ biphasic pleural … [Read more...]

Filed Under: Medicine, Mesothelioma Tagged With: pleural mesothelioma

Validation of Inflammatory Prognostic Biomarkers in Pleural Mesothelioma

April 16, 2024 By Thomas Lamb

Asbestos exposure is known as the main elicitor of pleural mesothelioma (PM) development. The pathology’s rarity, wide range of growth patterns, and devastating prognosis have hindered a standardized treatment to date. This study intended to determine possible prognosticators contributing to adjusting the treatment allocation. This initiated the … [Read more...]

Filed Under: Medicine, Mesothelioma Tagged With: mesothelioma, mesothelioma treatments, pleural mesothelioma

Impact of Surgery on Disease Progression and Survival of Patients with Pleural Mesothelioma

March 8, 2024 By Thomas Lamb

BACKGROUND:  The effects of surgery on the survival of patients with pleural mesothelioma remain poorly understood. We compared the therapeutic outcomes of patients receiving neoadjuvant chemotherapy followed by surgery or refusing surgery for pleural mesothelioma. METHODS:  This retrospective study included consecutive [ patients with pleural … [Read more...]

Filed Under: Medicine, Mesothelioma, Uncategorized Tagged With: meso, mesothelioma treatments, pleural mesothelioma

Pegargiminase Confers Survival Benefit in Nonepithelioid Pleural Mesothelioma

February 21, 2024 By Thomas Lamb

Adding pegargiminase to standard chemotherapy can improve outcomes in patients with chemotherapy-naïve, nonepithelioid pleural mesothelioma, according to research published in JAMA Oncology. [Szlosarek PW, Creelan BC, Sarkodie T, et al. Pegargiminase plus first-line chemotherapy in patients with nonepithelioid pleural mesothelioma. The ATOMIC-Meso … [Read more...]

Filed Under: Medicine, Mesothelioma Tagged With: mesothelioma, mesothelioma treatments, nonepithelioid pleural mesothelioma, Pegargiminase, pleural mesothelioma

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