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Niraparib plus Dostarlimab in Pleural Mesothelioma or Non-Small Cell Lung Cancer harboring HRR mutations: interim results of the UNITO-001 phase 2 prospective trial

January 15, 2024 By Thomas Lamb

Introduction: Treatment of homologous recombination repair deficient (HRD)-tumours with PARP inhibitors has the potential to further increase tumour immunogenicity, suggesting a synergistic effect with immunotherapy. Here we present the preliminary results of [ combination of niraparib plus dostarlimab ] for pleural mesothelioma (PM) or non-small … [Read more...]

Filed Under: Medicine, Mesothelioma Tagged With: mesothelioma, mesothelioma treatments, pleural mesothelioma

Pembrolizumab Plus Lenvatinib as Second- and Third-Line Treatments of Pleural Mesothelioma

October 30, 2023 By Thomas Lamb

In a Dutch single-institution phase II trial (PEMMELA) reported in The Lancet Oncology, Douma et al found that the combination of pembrolizumab and lenvatinib showed activity as second- and third-line treatments of patients with pleural mesothelioma. Study Details A total of 38 evaluable patients with disease progression after … [Read more...]

Filed Under: Medicine, Mesothelioma, Uncategorized Tagged With: lenvatinib, meso, mesothelioma treatments, pembrolizumab, pleural mesothelioma

Pembrolizumab plus lenvatinib in second-line and third-line patients with pleural mesothelioma (PEMMELA): a single-arm phase 2 study

October 16, 2023 By Thomas Lamb

Background:  The combination of pembrolizumab, an anti-PD-1 antibody, and lenvatinib, an antiangiogenic multikinase inhibitor, shows synergistic activity in preclinical and clinical studies in solid tumours. We assessed the clinical activity of this combination therapy [ of pembrolizumab plus lenvatinib ] in patients with pleural mesothelioma who … [Read more...]

Filed Under: Medicine, Mesothelioma, Uncategorized Tagged With: lenvatinib, mesothelioma treatments, pembrolizumab, pleural mesothelioma

Feladilimab by GSK for Malignant Pleural Mesothelioma: Likelihood of Approval

August 28, 2023 By Thomas Lamb

[Feladilimab] is under development [by the pharmaceutical company GSK] for the treatment of [malignant pleural mesothelioma], advanced solid tumors including non-small cell lung cancer, squamous non-small cell lung cancer, bladder cancer, cervical cancer, esophageal, urothelial cancer, clear renal cell carcinoma, head and neck cancer squamous cell … [Read more...]

Filed Under: Medicine, Mesothelioma Tagged With: malignant pleural mesothelioma (MPM), mesothelioma treatments, pleural mesothelioma

Pleural Mesothelioma: A Rapid Evolution of an Indolent Disease

January 20, 2023 By Thomas Lamb

Mesothelioma is a rare and insidious neoplasm and is characterized by its highly malignant and aggressive nature. The most common etiology is asbestos exposure, but there are some reports without known asbestos exposure and other factors leading to malignant pleural mesothelioma (MPM). Here, we present the case of a 58-year-old woman with … [Read more...]

Filed Under: Asbestos, Mesothelioma Tagged With: asbestos, malignant pleural mesothelioma (MPM), mesothelioma, pleural mesothelioma

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