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Clinical-pathological characteristics and prognostic factors for malignant peritoneal mesothelioma in the elderly

June 22, 2022 By Thomas Lamb

Background:  Malignant peritoneal mesothelioma (MPM) is a rare disease characterized by atypical symptoms, difficult diagnosis, variable course and poor prognosis, and it develops mainly in elderly individuals. The authors aimed to identify the clinical-pathological characteristics, prognosis, and prognostic factors in elderly [ malignant … [Read more...]

Filed Under: Medicine, Mesothelioma Tagged With: mesothelioma, peritoneal malignant mesothelioma, peritoneal mesothelioma

A Case Report of Hypophosphatemia Leading to the Diagnosis of Mesothelioma

June 8, 2022 By Thomas Lamb

Hypophosphatemia can be commonly encountered as an electrolyte imbalance and is defined as a value less than 0.8 mmol/l (2.5 mg/dl). It can be an incidental finding, but it is not uncommon to see it presenting with varied symptoms. It is good to have a clear diagnostic approach to this so adequate treatment can be instated. We present a … [Read more...]

Filed Under: Medicine, Mesothelioma Tagged With: hypophosphatemia, malignant mesothelioma, mesothelioma, mesothelioma diagnosis

J&J, 2-stepping through talc litigation, faces fresh claims it hid workers’ asbestos exposure

May 23, 2022 By Thomas Lamb

Johnson & Johnson’s yearslong talc litigation saga has taken an unexpected turn. U.S. Bankruptcy Judge Michael Kaplan this week denied J&J’s bid to block a lawsuit [ in the talc litigation ] accusing the company of hiding evidence that its industrial talc operations exposed workers to asbestos, Bloomberg first reported. Decades back, … [Read more...]

Filed Under: Asbestos, Claims, Exposure, Lawsuits, Talc Tagged With: asbestos talc lawsuits, asbestos-contaminated talc, asbestos-infused talc

CDC: Mesothelioma Deaths Up Among Women

May 13, 2022 By Thomas Lamb

While use of asbestos has gone down in the U.S., deaths from mesothelioma still increased 25% among women over the last two decades, researchers found. From 1999 to 2020, mesothelioma deaths among women rose significantly from 489 to 614, though the age-adjusted death rate per 1 million women fell from 4.83 to 4.15, reported Jacek Mazurek, MD, … [Read more...]

Filed Under: Facts, Mesothelioma Tagged With: malignant mesothelioma, mesothelioma

Unexplained Pleural Effusion Leads to the Revelation of a Malignant Mesothelioma: A Case Report

April 29, 2022 By Thomas Lamb

Abstract:  Malignant mesothelioma is a rare and aggressive cancer that usually affects subjects with prior asbestos exposure, a major risk factor that has been widely known as carcinogenic, and its use is now controlled if not banned in many areas of the world. Malignant mesothelioma originates from mesothelial surface cells covering the serous … [Read more...]

Filed Under: Medicine, Mesothelioma Tagged With: malignant mesothelioma, mesothelioma diagnosis, pleural effusions

Pericardial Mesothelioma Presenting as Constrictive Pericarditis

April 21, 2022 By Thomas Lamb

Abstract:  This case report presents a 60-year-old gentleman with a significant smoking history and possible asbestos exposure who was referred to the emergency department for atrial fibrillation with a rapid ventricular rate and symptoms of heart failure. Labs showed normal brain natriuretic peptide and troponin I. His echocardiography finding … [Read more...]

Filed Under: Medicine, Mesothelioma Tagged With: malignant mesothelioma, mesothelioma, mesothelioma diagnosis, pericardial mesothelioma

Abemaciclib for Previously Treated Patients With p16ink4A-Deficient Mesothelioma

April 15, 2022 By Thomas Lamb

As reported in The Lancet Oncology by Dean A. Fennell, FRCP, and colleagues, a phase II trial (MiST2) showed the activity of [ Verzenio (abemaciclib) ] in previously treated patients with p16ink4A-deficient malignant mesothelioma. As stated by the investigators, “Genetically stratified therapy for malignant mesothelioma is unavailable. … [Read more...]

Filed Under: Medicine, Mesothelioma Tagged With: abemaciclib, malignant mesothelioma, mesothelioma, mesothelioma treatments, Verzenio

EPA rule would finally ban asbestos, carcinogen still in use

April 7, 2022 By Thomas Lamb

The Environmental Protection Agency on Tuesday proposed a rule to finally ban asbestos, a carcinogen that is still used in some chlorine bleach, brake pads and other products and kills thousands of Americans every year. The proposal marks a major expansion of EPA regulation under a landmark 2016 law that overhauled rules governing tens of … [Read more...]

Filed Under: Asbestos, Exposure, Facts, Law Tagged With: asbestos, asbestos exposure, chrysotile asbestos, Environmental Protection Agency (EPA)

Early Clinical Activity With CDK4/6 Inhibitor in Pretreated Mesothelioma

March 11, 2022 By Thomas Lamb

[Verzenio (abemaciclib), a drug that has proven effective in breast cancer,] showed preliminary activity in its first-ever clinical trial in mesothelioma. The cyclin-dependent kinase (CDK) 4/6 inhibitor [Verzenio (abemaciclib)] achieved disease control at 12 weeks in 14 of 26 patients with progressive mesothelioma associated with a CDKN2A … [Read more...]

Filed Under: Medicine, Mesothelioma Tagged With: abemaciclib, malignant mesothelioma, mesothelioma, mesothelioma treatments, Verzenio

Biphasic Peritoneal Mesothelioma: A Lethal Clinical Entity

February 28, 2022 By Thomas Lamb

Abstract:  Mesotheliomas are a rare malignancy of the serosal membrane. Mainly it affects the pleural surfaces followed by the second most common location, “peritoneum.” The disease follows an aggressive pattern of spread, and by the time the diagnosis is established, the condition significantly spreads to distant locations. Diagnosis of malignant … [Read more...]

Filed Under: Medicine, Mesothelioma Tagged With: biphasic peritoneal mesothelioma, mesothelioma, peritoneal malignant mesothelioma, peritoneal mesothelioma

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